Alzheimer's disease

Alzheimer's disease

Well most of us have a very narrow knowledge related to this magnificent disease which is Alzheimer's disease, In my point of view and my anticipations says that most of those whom I know knows only that Alzheimer means memory loss, well yes it is but that's not only its symptom, Alzheimer's disease is kind of a successful disease (a brain disorder); due to a couple of reasons but firstly, it has been discovered in 1906 by Dr. Alois Alzheimer a German psychiatrist, and guess what people 110 years since its discovery yet none ever could find a cure to eliminate Alzheimer's disease, the only treatment reached so far are only made to slow its progression.
To be honest in front of you all, I am really afraid since the day I have read about this disease, it scares me and I felt so sorry for those who has it and those who died of it. God be with you.
Anyway, Alzheimer's disease not only loosens its patient his memory but also it causes several damage to him, Symptoms starts by: 1)Short memory loss
2)Lack of the ability to perform logical thoughts
3)Erratic mood changes (through infecting the part that controls emotions in the brain)
4)Paranoia and hallucinations
5)Long term memory loss
Eventually 6)It takes over the control centers leading to a fail in pumping blood as well as breathing resulting to death.
How Alzheimer's disease progress ?
Through an autopsy( an examination that is done to the person after his death (corpse) to evaluate and identify the reasons of the death through a highly surgical operation, they found out in the brain structure the presense of misfolded proteins ( meaning they are not in their suitable or right place) Protein folding is a process by which the protein molecules tend to attach together in order to arrange its functional shape, the misfolded proteins are called plaques (are small differentiated areas on the body surface or on organs such as the brain in our case) plaques are formed when an enzyme slices the fatty membrane surrounding the nerve cells (mylein sheath) resulting in beta-amyloid proteins ( these proteins' role is neural growth and repair any damage ) but any corrupted form later in life leads to the lose of memory among other things, they then group together due to their sticky status which form what we mentioned ''plaques'' their grouping blocks the cell signaling such as any messenger proteins and pulses and therefore the communcation between cells, these defected cells due to the formation of these plaques and tangles lead to the triggering of immune reactions causing the destruction of the disabled nerve cells and also found neurofibrillary tangles neurofibrillary (nerve fibers) tangles ( grouping) so neurofibrillary tangles are the grouping of nerve fibers in a confusing way making a complex structure, they are built from a protein known as tau ( tau protein is a protein that tends to stabilize the microtubules found in the neurons of the central nervous system which is more likely to be a network that receives oxygen, food molecules and nutrients to the brain's nerve cells.

In Alzheimer's disease these proteins becomes twisted strands meaning the passage of nutrients to the brain's nerve cells are obstructed which leads to the death of these cells eventually.

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Just in case everyone since I have noticed the video is not working properly, here is a direct link to the video on youtube I am so sorry: https://www.youtube.com/watch?v=yJXTXN4xrI8

Figure showing how Alzheimer's disease on the brain
Thanks to Alzheimer's association for developing this picture showing us the result of the destructive pairing of plaques and tangles on some brain parts